Drawing on the power of DNA sequencing, National Institutes of Health researchers have identified a new group of genetic mutations involved in the deadliest form of skin cancer, melanoma. This discovery is particularly encouraging because some of the mutations, which were found in nearly one-fifth of melanoma cases, reside in a gene already targeted by a drug approved for certain types of breast cancer.
More...Protein Involved In Causing Gum Disease, Osteoporosis, Arthritis Identified
Article Date: 01 Sep 2009
Investigators at Hospital for Special Surgery, collaborating with researchers from other institutions, have contributed to the discovery that a gene called interferon regulator factor-8 (IRF-8) is involved in the development of diseases such as periodontitis (gum disease), rheumatoid arthritis and osteoporosis. The study, which was published online August 30, ahead of print, in the journal Nature Medicine, could lead to new treatments in the future.
More...Antimicrobial Antibodies In Celiac Disease: Trick Or Treat?
Article Date: 27 Sep 2009
Anti-microbial antibody formation has been reported in celiac disease. Relatively high positivity rates were observed for the conventional antibodies, for example, ASCA, anti-OmpW, and anti-I2, and they were known to decrease after a successful gluten free-diet. The importance of newly discovered inflammatory bowel disease-associated antibodies (including anti-glycan antibodies and anti-OMP) in celiac disease is not sure. The presence of anti-microbial antibodies in relation to clinical presentation of the disease and NOD2/CARD15 mutations was also not investigated.
More...Discovery Of 'Fatostatin' A Turnoff For Fat Genes
Article Date: 28 Sep 2009
A small molecule earlier found to have both anti-fat and anti-cancer abilities works as a literal turnoff for fat-making genes, according to a new report in the August 28th issue of the journal Chemistry and Biology, a Cell Press journal.
More...Moderate Drinkers Less Likely To Develop Dementia
Article Date: 29 Sep 2009
People who drink light to moderate amounts of alcohol in later life are less likely to develop dementia than people who abstain from alcohol consumption, a study from The Australian National University has found.
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